AUTHOR=Frontino Giulio , Di Tonno Raffaella , Castorani Valeria , Rigamonti Andrea , Morotti Elisa , Sandullo Federica , Scialabba Francesco , Arrigoni Francesca , Foglino Riccardo , Dionisi Benedetta , Ferri Chiara Irene Carla , Zirpoli Salvatore , Barera Graziano , Meschi Franco , Bonfanti Riccardo TITLE=Non-Occlusive Mesenteric Ischemia in Children With Diabetic Ketoacidosis: Case Report and Review of Literature JOURNAL=Frontiers in Endocrinology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.900325 DOI=10.3389/fendo.2022.900325 ISSN=1664-2392 ABSTRACT=Introduction

Despite the use of technology, recurrent diabetic ketoacidosis (DKA) prevention remains an unmet need in children and adolescents with T1D and may be accompanied by life-threatening acute complications. We present a rare case of non-occlusive mesenteric ischemia (NOMI) with overt manifestation after DKA resolution and a discussion of recent literature addressing DKA-associated NOMI epidemiology and pathogenesis in children and adolescents.

Case Presentation

A 13-year-old female with previously diagnosed T1D, was admitted at our emergency department with hypovolemic shock, DKA, hyperosmolar state and acute kidney injury (AKI). Mildly progressive abdominal pain persisted after DKA correction and after repeated ultrasound evaluations ultimately suspect for intestinal perforation, an intraoperative diagnosis of NOMI was made.

Conclusion

The diagnosis of DKA-associated NOMI must be suspected in pediatric patients with DKA, persistent abdominal pain, and severe dehydration even after DKA resolution.