AUTHOR=Liang Yuan , Yu Ruili , He Rui , Sun Lijun , Luo Chao , Feng Lu , Chen Hong , Yin Yue , Zhang Weizhen 

TITLE=Lower ghrelin levels does not impact the metabolic benefit induced by Roux-en-Y gastric bypass

JOURNAL=Frontiers in Endocrinology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.891379

DOI=10.3389/fendo.2022.891379

ISSN=1664-2392

ABSTRACT=<sec><title>Objective</title><p>Roux-en-Y gastric bypass is an effective intervention for metabolic disorder. We aim to elucidate whether ghrelin contributes to weight reduction, and glycemic and lipid control after Roux-en-Y gastric bypass (RYGB).</p></sec><sec><title>Design</title><p>Four-week-old WT and Ghrl-TSC1<sup>-/-</sup> mice were fed high fat diet for 12 weeks before surgery, and continued to be on the same diet for 3 weeks after surgery. Body weight, food intake, glycemic and lipid metabolism were analyzed before and after surgery.</p></sec><sec><title>Results</title><p>Gastric and circulating ghrelin was significantly increased in mice with RYGB surgery. Hypoghrelinemia elicited by deletion of TSC1 to activate mTOR signaling in gastric X/A like cells demonstrated no effect on weight reduction, glycemic and lipid control induced by Roux-en-Y gastric bypass surgery.</p></sec><sec><title>Conclusion</title><p>Lower ghrelin levels does not impact the metabolic benefit induced by Roux-en-Y gastric bypass.</p></sec>