AUTHOR=Mao Fei , Wang E. , Xu Jing , Lu Jin , Yan Guofeng , Fu Li , Jiao Yang , Wu Ling , Liu Tiemin , Li Yao 

TITLE=Transcriptome Analysis of Multiple Metabolic Tissues in High-Salt Diet–Fed Mice

JOURNAL=Frontiers in Endocrinology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.887843

DOI=10.3389/fendo.2022.887843

ISSN=1664-2392

ABSTRACT=<p>High-salt diet (HSD) is associated with dysregulated metabolism and metabolic disorders. Although previous studies have indicated its effect on metabolic tissues, the involving molecular mechanisms are not quite understood. In the present study, we provided a comprehensive transcriptome analysis on multiple metabolic tissues of HSD-fed mouse model by RNA sequencing. We observed that several genes associated with <italic>de novo</italic> lipogenesis and cholesterol biosynthesis were significantly downregulated in white adipose tissue and liver tissue of HSD mice group, such as <italic>Fasn</italic>, <italic>Scd1</italic>, <italic>Acaca</italic>, and <italic>Thrsp.</italic> Furthermore, combined with secretome datasets, our results further demonstrated that HSD could alter expression levels of organokines in metabolic tissues, for example, <italic>Tsk</italic> and <italic>Manf</italic>, in liver tissue and, thus, possibly mediate cross-talk between different metabolic tissues. Our study provided new insight about molecular signatures of HSD on multiple metabolic tissues.</p>