AUTHOR=Zhang Chongjing , Zhong Zeyuan , Sang Weicong , Ghorbani Farnaz , Ghalandari Behafarid , Mohamadali Marjan , Irani Shiva , Qian Zhi , Yi Chengqing , Yu Baoqing TITLE=The Dibenzyl Isoquinoline Alkaloid Berbamine Ameliorates Osteoporosis by Inhibiting Bone Resorption JOURNAL=Frontiers in Endocrinology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.885507 DOI=10.3389/fendo.2022.885507 ISSN=1664-2392 ABSTRACT=
Postmenopausal osteoporosis (PMOP) is a kind of primary osteoporosis that is characterized by decreased bone density and strength. Berbamine is a nonbasic quaternary benzylisoquinoline plant alkaloid that has been widely used in the clinic to treat leukopenia in China. We found that berbamine inhibited RANKL-induced osteoclastogenesis of bone marrow-derived macrophages (BMMs)