AUTHOR=Liu Runzhu , Dong Ruijia , Chang Mengling , Liang Xiao , Wang Hayson Chenyu 

TITLE=Adipose-Derived Stem Cells for the Treatment of Diabetic Wound: From Basic Study to Clinical Application

JOURNAL=Frontiers in Endocrinology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.882469

DOI=10.3389/fendo.2022.882469

ISSN=1664-2392

ABSTRACT=<p>Diabetic wounds significantly affect the life quality of patients and may cause amputation and mortality if poorly managed. Recently, a wide range of cell-based methods has emerged as novel therapeutic methods in treating diabetic wounds. Adipose-derived stem cells (ASCs) are considered to have the potential for widespread clinical application of diabetic wounds treatment in the future. This review summarized the mechanisms of ASCs to promote diabetic wound healing, including the promotion of immunomodulation, neovascularization, and fibro synthesis. We also review the current progress and limitations of clinical studies using ASCs to intervene in diabetic wound healing. New methods of ASC delivery have been raised in recent years to provide a standardized and convenient use of ASCs.</p>