AUTHOR=Pánico Pablo , Velasco Myrian , Salazar Ana María , Picones Arturo , Ortiz-Huidobro Rosa Isela , Guerrero-Palomo Gabriela , Salgado-Bernabé Manuel Eduardo , Ostrosky-Wegman Patricia , Hiriart Marcia 

TITLE=Is Arsenic Exposure a Risk Factor for Metabolic Syndrome? A Review of the Potential Mechanisms

JOURNAL=Frontiers in Endocrinology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.878280

DOI=10.3389/fendo.2022.878280

ISSN=1664-2392

ABSTRACT=<p>Exposure to arsenic in drinking water is a worldwide health problem. This pollutant is associated with increased risk of developing chronic diseases, including metabolic diseases. Metabolic syndrome (MS) is a complex pathology that results from the interaction between environmental and genetic factors. This condition increases the risk of developing type 2 diabetes, cardiovascular diseases, and cancer. The MS includes at least three of the following signs, central obesity, impaired fasting glucose, insulin resistance, dyslipidemias, and hypertension. Here, we summarize the existing evidence of the multiple mechanisms triggered by arsenic to developing the cardinal signs of MS, showing that this pollutant could contribute to the multifactorial origin of this pathology.</p>