AUTHOR=Ruan Yongsheng , Chen Libai , Xie Danfeng , Luo Tingting , Xu Yiqi , Ye Tao , Chen Xiaona , Feng Xiaoqin , Wu Xuedong 

TITLE=Mechanisms of Cell Adhesion Molecules in Endocrine-Related Cancers: A Concise Outlook

JOURNAL=Frontiers in Endocrinology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.865436

DOI=10.3389/fendo.2022.865436

ISSN=1664-2392

ABSTRACT=<p>Chemotherapy is a critical treatment for endocrine-related cancers; however, chemoresistance and disease recurrence remain a challenge. The interplay between cancer cells and the tumor microenvironment <italic>via</italic> cell adhesion molecules (CAMs) promotes drug resistance, known as cell adhesion-mediated drug resistance (CAM-DR). CAMs are cell surface molecules that facilitate cell-to-cell or cell-to-extracellular matrix binding. CAMs exert an adhesion effect and trigger intracellular signaling that regulates cancer cell stemness maintenance, survival, proliferation, metastasis, epithelial–mesenchymal transition, and drug resistance. To understand these mechanisms, this review focuses on the role of CD44, cadherins, selectins, and integrins in CAM-DR in endocrine-related cancers.</p>