AUTHOR=Wei Yaping , Han Shiyu , Zhou Ruonan , Xu Pingyuan , Zhou Lingyan , Zhu Ziwei , Kan Yue , Yang Xiaoying , Xiang Yingying , Cao Yue , Jin Yu , Yan Jing , Yu Xizhong , Wang Xin , Shang Wenbin 

TITLE=Increased Serum VEGF-B Level Is Associated With Renal Function Impairment in Patients With Type 2 Diabetes

JOURNAL=Frontiers in Endocrinology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.862545

DOI=10.3389/fendo.2022.862545

ISSN=1664-2392

ABSTRACT=<sec><title>Aims/Introduction</title><p>Renal function impairment related to type 2 diabetes (T2DM) presents serious threat to public health. Previous studies suggest that vascular endothelial growth factor-B (VEGF-B) might contribute to renal injury. Therefore, this study investigated the association of serum VEGF-B level with the risk of renal function impairment in T2DM patients.</p></sec><sec><title>Materials and Methods</title><p>Serum VEGF-B levels were measured in 213 patients with type 2 diabetes and 31 healthy participants. Participants with type 2 diabetes were further divided into a group of 112 participants with eGFR&lt;90 mL/min/1.73m<sup>2</sup> and 101 participants with eGFR≥ 90 mL/min/1.73m<sup>2</sup>. Clinical data were collected, and a binary logistic regression model was employed to test the association between potential predictors and eGFR.</p></sec><sec><title>Results</title><p>Serum VEGF-B levels evaluated in type 2 diabetes patients compared with healthy controls. In patients with type 2 diabetes, serum VEGF-B level was positively correlated with triglyceride, serum creatinine and cystatin C while negatively correlated with HDL-C and eGFR. Binary logistic regression showed that serum VEGF-B level was an independent risk factor of eGFR&lt;90 mL/min/1.73m<sup>2</sup>.</p></sec><sec><title>Conclusions</title><p>Serum VEGF-B level is associated with renal function impairment in patients with type 2 diabetes and may be a potential drug target for diabetic kidney disease.</p></sec>