AUTHOR=Oziel-Taieb Sandrine , Maniry-Quellier Jemima , Chanez Brice , Poizat Flora , Ewald Jacques , Niccoli Patricia 

TITLE=Pasireotide for Refractory Hypoglycemia in Malignant Insulinoma- Case Report and Review of the Literature

JOURNAL=Frontiers in Endocrinology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.860614

DOI=10.3389/fendo.2022.860614

ISSN=1664-2392

ABSTRACT=<p>Malignant insulinomas are functional neuroendocrine tumors of the pancreas and the primary cause of tumor-related hypoglycemia. Malignant insulinoma is rare and has a poor prognosis. We report a case of metastatic malignant insulinoma in a 64-year-old female patient with severe and refractory hypoglycemia. After several ineffective locoregional and systemic therapeutic lines for the secretory disease, the introduction of pasireotide, a second-generation somatostatin analog, provided an improved clinical and secretory evolution both quickly and sustainably, with an excellent safety profile. Pasireotide is an effective and well-tolerated therapy in the treatment of refractory hypoglycemia in metastatic insulinoma.</p>