AUTHOR=Xu Jian , Yang Li , Chen Zhi-Heng , Yin Min-Na , Chen Juan , Sun Ling 

TITLE=Oocytes With Smooth Endoplasmic Reticulum Aggregates May Not Impact Blastocyst Euploidy Rate

JOURNAL=Frontiers in Endocrinology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.851370

DOI=10.3389/fendo.2022.851370

ISSN=1664-2392

ABSTRACT=<sec><title>Objective</title><p>To investigate whether the euploidy rate of blastocysts derived from smooth endoplasmic reticulum aggregates (SERa) positive cycles and oocytes are impacted.</p></sec><sec><title>Design</title><p>Retrospective cohort study.</p></sec><sec><title>Method(s)</title><p>A total of 601 preimplantation genetic testing (PGT) cycles with at least one oocyte retrieved in our center between April 2017 and May 2021 were initially included in the study. Women&gt;35 years and PGT cycles with chromosomal structural rearrangements (PGT-SR) were excluded. Embryological and blastocyst ploidy outcomes were compared among SERa+ oocyte, sibling SERa- oocytes and oocytes in SERa- cycles.</p></sec><sec><title>Results</title><p>No significant difference was observed among the SERa+ oocyte group, sibling SERa- oocyte group, and SERa- cycle group in the normal fertilization rate (82.1% vs. 77.8% vs. 83.1%, respectively, <italic>P</italic>=0.061), blastocyst formation rate (71.0% vs. 72.5% vs. 68.4%, respectively, <italic>P</italic>=0.393), good quality blastocyst formation rate (46.4% vs. 48.3% vs. 42.6%, respectively, <italic>P</italic>=0.198). No significant difference was observed in the euploidy rate (50.0% vs. 62.5% vs. 63.3%, respectively, <italic>P</italic>=0.324), mosaic rate (12.5% vs. 9.7% vs. 13.4%, respectively, <italic>P</italic>=0.506), and aneuploidy rate (37.5% vs. 27.8% vs. 23.2%, respectively, <italic>P</italic>=0.137) among the three groups.</p></sec><sec><title>Conclusion</title><p>Our results suggest that the euploidy rate of blastocysts derived from SERa+ cycles and oocytes may not be impacted.</p></sec>