AUTHOR=Jia Xiaomeng , Wang Anping , Yang Longyan , Cheng Yu , Wang Yajing , Ba Jianming , Dou Jingtao , Mu Yiming , Zhao Dong , Lyu Zhaohui 

TITLE=Clinical Significance of Lifetime Maximum Body Mass Index in Predicting the Development of T2DM: A Prospective Study in Beijing

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.839195

DOI=10.3389/fendo.2022.839195

ISSN=1664-2392

ABSTRACT=Background: Overweight and obesity are well-known risk factors for type 2 diabetes (T2DM). While the effect of the maximum body mass index (BMImax), which indicates the highest body weight, before the diagnosis of diabetes is not fully understood. This study aimed to explore the predictive value of BMImax on the progression of diabetes.
Methods: This prospective study recruited 2018 subjects with normal glucose tolerance in Beijing, China. all the subjects were followed up for eight years, and the association between BMImax and glucose outcome was evaluated.
Results: 97 of 2,018 participants developed diabetes at the end of the study. Compared to individuals with normal glucose tolerance, those who developed diabetes were characterized by higher levels of fasting plasma glucose (FPG), 2 h postload glucose (PBG), glycosylated hemoglobin (HbA1c), systolic blood pressure (SBP), and low-density lipoprotein cholesterol (LDL-c), familial history of diabetes and a lower titer of high‐density lipoprotein cholesterol (HDL-c). Multivariate regression analysis suggested that FPG, HbA1c, SBP and familial history were independent risk factors for diabetes, but BMImax was unique indicators in females.
Conclusions: BMImax might be an independent predictor of diabetes in females, but it does not seem to be associated with the risk of diabetes in males. BMImax could be regarded as an indicator in the prevention and management of diabetes.