AUTHOR=Tu Mixue , Wu Yiqing , Wang Feixia , Huang Yun , Qian Yuli , Li Jingyi , Lv Pingping , Ying Yanyun , Liu Juan , Liu Yifeng , Zhang Runju , Zhao Wei , Zhang Dan TITLE=Effect of lncRNA MALAT1 on the Granulosa Cell Proliferation and Pregnancy Outcome in Patients With PCOS JOURNAL=Frontiers in Endocrinology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.825431 DOI=10.3389/fendo.2022.825431 ISSN=1664-2392 ABSTRACT=
Follicle arrest is one of the main characteristics of polycystic ovary syndrome (PCOS), the most common endocrinological disorder in reproductive-aged women. Increasing evidence proves that high anti-Mullerian hormone (AMH) levels may play an important role in follicular development. Long noncoding RNA (lncRNA) with a length of more than 200 nt is widely involved in the directional differentiation, growth, and development of cells, whereas whether lncRNA is involved in AMH’s role in follicular development is unknown. In this study, we analyzed lncRNA expression in ovarian granulosa cells (GCs) collected from women with and without PCOS