AUTHOR=Du Wei , Shi Xiangyu , Fang Qigen , Zhang Xu , Liu Shanting 

TITLE=Feasibility of Apatinib in Radioiodine-Refractory Differentiated Thyroid Carcinoma

JOURNAL=Frontiers in Endocrinology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.768028

DOI=10.3389/fendo.2022.768028

ISSN=1664-2392

ABSTRACT=<sec><title>Objectives</title><p>Our aim was to describe our experience in using apatinib as treatment for radioiodine-refractory differentiated thyroid carcinoma (RAIR-DTC).</p></sec><sec><title>Methods</title><p>Forty-seven patients undergoing apatinib treatment for RAIR-DTC were prospectively enrolled in this study. The study endpoints were objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), overall survival (OS), and rate of adverse events.</p></sec><sec><title>Results</title><p>No patients achieved complete response, while 36 (76.6%) and 8 (17.0%) patients achieved partial response and stable disease, respectively. The ORR and DCR were 76.6% and 93.6%, respectively. The median PFS and OS were 18 and 59 months, respectively. A total of 91 adverse events occurred, of which 21 were graded as grade 3 or higher. There were no drug-related deaths.</p></sec><sec><title>Conclusions</title><p>Apatinib has distinct anti-RAIR-DTC efficacy in terms of ORR, PFS, and OS and has a favorable safety profile. It is a feasible treatment option for RAIR-DTC.</p></sec>