AUTHOR=Zhou Qingluo , Ren Qun , Jiao Linhui , Huang Jishang , Yi Jun , Chen Jincai , Lai Jinliang , Ji Guanglin , Zheng Tiansheng 

TITLE=The potential roles of JAK/STAT signaling in the progression of osteoarthritis

JOURNAL=Frontiers in Endocrinology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.1069057

DOI=10.3389/fendo.2022.1069057

ISSN=1664-2392

ABSTRACT=<p>Osteoarthritis (OA) is an age-related chronic progressive degenerative disease that induces persistent pain and disabilities. The development of OA is a complex process, and the risk factors are various, including aging, genetics, trauma and altered biomechanics. Inflammation and immunity play an important role in the pathogenesis of OA. JAK/STAT pathway is one of the most prominent intracellular signaling pathways, regulating cell proliferation, differentiation, and apoptosis. Inflammatory factors can act as the initiators of JAK/STAT pathway, which is implicated in the pathophysiological activity of chondrocyte. In this article, we provide a review on the importance of JAK/STAT pathway in the pathological development of OA. Potentially, JAK/STAT pathway becomes a therapeutic target for managing OA.</p>