AUTHOR=Zhou Wan , Li Jie , Yuan Xiaojing , Wang Wei , Zhou Huanran , Zhang Haoqiang , Ye Shandong 

TITLE=Application of urine C-peptide creatinine ratio in type 2 diabetic patients with different levels of renal function

JOURNAL=Frontiers in Endocrinology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.1052794

DOI=10.3389/fendo.2022.1052794

ISSN=1664-2392

ABSTRACT=<sec><title>Objective</title><p>This study aims to investigate the effect of single urine C peptide/creatinine (UCPCR) in assessing the islet β Cell function of type 2 diabetes mellitus (T2DM) patients with different renal function.</p></sec><sec><title>Methods</title><p>A total of 85 T2DM patients were recruited in this study, all the patients were assigned to one group with estimated glomerular filtration rate (eGFR)≤60 ml·min<sup>-1</sup>·1.73 m<sup>-2</sup> and another group complicated with eGFR&gt;60 ml·min<sup>-1</sup>·1.73 m<sup>-2</sup>. Serum creatinine, urine creatinine, serum fasting C-peptide (FCP), fasting blood glucose (FBG), glycosylated hemoglobin (HbA1C) and 24-hour urinary C-peptide (24hUCP) were measured. The modified homeostasis model assessment-islet β cell function [HOMA-islet (CP-DM)], the modified homeostasis model assessment-insulin resistance [HOMA-IR(CP)] and UCPCR were calculated.</p></sec><sec><title>Results</title><p>When compared with group eGFR ≤60 ml·min<sup>-1</sup>·1.73 m<sup>-2</sup>, the levels of UCPCR, FCP, the modified HOMA-IR(CP) and HOMA-islet (CP-DM) were promoted and the concentrations of HbA1C, FPG, creatinine were decreased in the patients of eGFR&gt;60 ml·min<sup>-1</sup>·1.73 m<sup>-2</sup> (<italic>P</italic>&lt;0.05); FCP was uncorrelated with 24hUCP while associated with UCPCR in the patients of eGFR ≤ 60 ml·min<sup>-1</sup>·1.73 m<sup>-2</sup>; UCPCR was positively correlated with FCP and HOMA-IR(CP) in the T2DM patients with different levels of renal function; the cut-off (UCPCR ≤ 1.13 nmol/g) had 88.37% sensitivity and 95.24% specificity [95% confidence interval (CI):0.919-0.997] for identifying severe insulin deficiency in T2DM patients[area under the curve (AUC) 0.978].</p></sec><sec><title>Conclusion</title><p>UCPCR can be used to evaluate islets β Cell function in T2DM patients with different renal function status.</p></sec>