AUTHOR=Petersen Maria Houborg , de Almeida Martin Eisemann , Wentorf Emil Kleis , Jensen Kurt , Ørtenblad Niels , Højlund Kurt 

TITLE=High-intensity interval training combining rowing and cycling efficiently improves insulin sensitivity, body composition and VO2max in men with obesity and type 2 diabetes

JOURNAL=Frontiers in Endocrinology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.1032235

DOI=10.3389/fendo.2022.1032235

ISSN=1664-2392

ABSTRACT=<sec><title>Aims</title><p>Non-weight-bearing high-intensity interval training (HIIT) involving several muscle groups may efficiently improve metabolic health without compromising adherence in obesity and type 2 diabetes. In a non-randomized intervention study, we examined the effect of a novel HIIT-protocol, recruiting both lower and upper body muscles, on insulin sensitivity, measures of metabolic health and adherence in obesity and type 2 diabetes.</p></sec><sec><title>Methods</title><p>In 15 obese men with type 2 diabetes and age-matched obese (<italic>n</italic>=15) and lean (<italic>n</italic>=18) glucose-tolerant men, the effects of 8-weeks supervised HIIT combining rowing and cycling on ergometers (3 sessions/week) were examined by DXA-scan, incremental exercise test and hyperinsulinemic-euglycemic clamp combined with indirect calorimetry.</p></sec><sec><title>Results</title><p>At baseline, insulin-stimulated glucose disposal rate (GDR) was ~40% reduced in the diabetic vs the non-diabetic groups (all <italic>p</italic>&lt;0.01). In response to HIIT, insulin-stimulated GDR increased ~30-40% in all groups (all <italic>p</italic>&lt;0.01) entirely explained by increased glucose storage. These changes were accompanied by ~8-15% increases in VO<sub>2</sub>max, (all <italic>p</italic>&lt;0.01), decreased total fat mass and increased lean body mass in all groups (all <italic>p</italic>&lt;0.05). There were no correlations between these training adaptations and no group-differences in these responses. HbA1c showed a clinically relevant decrease in men with type 2 diabetes (4±2 mmol/mol; <italic>p</italic>&lt;0.05). Importantly, adherence was high (&gt;95%) in all groups and no injuries were reported.</p></sec><sec><title>Conclusions</title><p>A novel HIIT-protocol recruiting lower and upper body muscles efficiently improves insulin sensitivity, VO<sub>2</sub>max and body composition with intact responses in obesity and type 2 diabetes. The high adherence and lack of injuries show that non-weight-bearing HIIT involving several muscle groups is a promising mode of exercise training in obesity and type 2 diabetes.</p></sec>