AUTHOR=Emanuel Rebecca H. K. , Roberts Josh , Docherty Paul D. , Lunt Helen , Campbell Rebecca E. , Möller Knut 

TITLE=A review of the hormones involved in the endocrine dysfunctions of polycystic ovary syndrome and their interactions

JOURNAL=Frontiers in Endocrinology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.1017468

DOI=10.3389/fendo.2022.1017468

ISSN=1664-2392

ABSTRACT=<p>Polycystic ovary syndrome (PCOS) affects up to 20% of women but remains poorly understood. It is a heterogeneous condition with many potential comorbidities. This review offers an overview of the dysregulation of the reproductive and metabolic systems associated with PCOS. Review of the literature informed the development of a comprehensive summarizing ‘wiring’ diagram of PCOS-related features. This review provides a justification for each diagram aspect from the relevant academic literature, and explores the interactions between the hypothalamus, ovarian follicles, adipose tissue, reproductive hormones and other organ systems. The diagram will provide an efficient and useful tool for those researching and treating PCOS to understand the current state of knowledge on the complexity and variability of PCOS.</p>