AUTHOR=Scheffler Florence , Vandecandelaere Albane , Soyez Marion , Bosquet Dorian , Lefranc Elodie , Copin Henri , Devaux Aviva , Benkhalifa Moncef , Cabry Rosalie , Desailloud Rachel 

TITLE=Follicular GH and IGF1 Levels Are Associated With Oocyte Cohort Quality: A Pilot Study

JOURNAL=Frontiers in Endocrinology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.793621

DOI=10.3389/fendo.2021.793621

ISSN=1664-2392

ABSTRACT=<sec><title>Introduction</title><p>Oocyte quality contributes to the development of an optimal embryo and thus a successful pregnancy. The objective of this study was to analyse the association between oocyte cohort quality and the follicular levels of growth hormone (GH), insulin-like growth factor 1 (IGF1), 25-hydroxy vitamin D (25OHD), thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4) and antithyroid antibodies, as a function of intracytoplasmic sperm injection (ICSI) outcomes.</p></sec><sec><title>Material and methods</title><p>We conducted a prospective comparative pilot study from January 2013 to December 2017. 59 ICSI cycles constituted an abnormal oocyte cohort (n=34 cycles, in which more than 50% of oocytes presented at least one morphological abnormality) and a normal oocyte cohort (n=25 cycles, in which 50% or less of the oocytes presented at least one morphological abnormality). GH, IGF1, 25OHD, TSH, fT3, fT4 and antithyroid antibodies were measured in follicular fluid.</p></sec><sec><title>Results</title><p>The fertilisation rate was lower in the abnormal oocyte cohort (65.5% <italic>vs.</italic> 80%, respectively, p=0.012). Oocytes’ proportion with at least one abnormality was 79.4% in the abnormal oocyte cohort and 29.0% in the normal oocyte cohort. The mean number of morphological abnormalities per oocyte was significantly higher in the abnormal oocyte cohort. The follicular levels of GH (4.98 <italic>vs.</italic> 2.75 mIU/L, respectively; p &lt;0.01) and IGF1 (72.1 <italic>vs.</italic> 54.2 ng/mL, respectively; p=0.05) were higher in the normal oocyte cohort. There was no association with follicular levels of TSH, fT3, fT4, antithyroid antibodies, or 25OHD.</p></sec><sec><title>Conclusion</title><p>Oocyte cohort quality appears to be associated with follicular levels of GH and IGF1.</p></sec>