AUTHOR=Panigoro Sonar Soni , Sutandyo Noorwati , Witjaksono Fiastuti , Siregar Nurjati Chairani , Ramli Ramadhan , Hariani Ririn , Pangarsa Eko Adhi , Prajoko Yan Wisnu , Puruhita Niken , Hamdani William , Bayu Dimas , Madjid Mardiana , Yulidar Dedy , Fransiska Jane Estherina , Widyawati Retno , Tripriadi Effif Syofra , F. W. Wiwit Ade , Yunda Dewi Krisna , Pranata Raymond 

TITLE=The Association Between Triglyceride-Glucose Index as a Marker of Insulin Resistance and the Risk of Breast Cancer

JOURNAL=Frontiers in Endocrinology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.745236

DOI=10.3389/fendo.2021.745236

ISSN=1664-2392

ABSTRACT=<sec><title>Background</title><p>This study aims to evaluate the association and dose-response between triglyceride-glucose (TyG) index and breast cancer.</p></sec><sec><title>Method</title><p>This is a multicenter case-control study conducted in six public referral hospitals in Indonesia. Cases are individuals aged 19 years or above who were diagnosed with breast cancer within 1 year of diagnosis, based on histopathology and immunohistochemistry. Controls were recruited from corresponding hospitals. TyG index was determined by the formula: ln (fasting TG [mg/dl] × fasting glucose [mg/dl]).</p></sec><sec><title>Results</title><p>There were 212 participants in the breast cancer group and 212 participants in the control group. TyG index was higher in patients with breast cancer (median 8.65 [7.38, 10.9] vs. 8.30 [7.09, 10.84], <italic>p</italic> &lt; 0.001). When compared with TyG quartile of Q1, Q4 was associated with an OR of 2.42 (1.77, 3.31), <italic>p</italic> &lt; 0.001, Q3 was associated with an OR of 1.53 (1.21, 1.93), <italic>p</italic> &lt; 0.001, Q2 was associated with an OR of 1.39 (1.12, 1.73), <italic>p</italic> = 0.002 for the risk of breast cancer. The dose-response relationship was nonlinear (<italic>p</italic> &lt; 0.001). On univariate analysis, smoking (OR 2.15 [1.44, 3.22], <italic>p</italic> &lt; 0.001), use of contraception (1.73 [1.15, 2.60], <italic>p</italic> = 0.008), alcohol consumption (OR 2.04 [0.96, 4.35], <italic>p</italic> = 0.064), and TyG Index &gt;8.87 (OR 3.08 [1.93, 4.93], <italic>p</italic> &lt; 0.001) were associated with risk of breast cancer. Independently associated with increased risk of breast cancer included smoking (OR 1.93 [1.23, 3.01], <italic>p</italic> = 0.004), use of contraception (OR 1.59 [1.02, 2.48], <italic>p</italic> = 0.039), and TyG Index &gt;8.87 (OR 2.93 [1.72, 4.98], <italic>p</italic> &lt; 0.001)</p></sec><sec><title>Conclusion</title><p>TyG index was associated with breast cancer in a nonlinear dose-response fashion.</p></sec>