AUTHOR=Wang Haoyu , Zhang Yu , Fang Xuhui , Kwak-Kim Joanne , Wu Li 

TITLE=Insulin Resistance Adversely Affect IVF Outcomes in Lean Women Without PCOS

JOURNAL=Frontiers in Endocrinology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.734638

DOI=10.3389/fendo.2021.734638

ISSN=1664-2392

ABSTRACT=<sec><title>Objective</title><p>To investigate the effects of insulin resistance (IR) on IVF outcomes and a potential underlying mechanism in lean women without PCOS.</p></sec><sec><title>Design</title><p>A prospective cohort study at the University Clinic.</p></sec><sec><title>Setting</title><p>IVF center at the University setting.</p></sec><sec><title>Patients</title><p>A total of 155 lean women (body mass index &lt;25) without PCOS undergoing IVF cycle.</p></sec><sec><title>Intervention</title><p>Patients were allocated to IR and non-IR groups based on HOMA-M<sub>120</sub>.</p></sec><sec><title>Main Outcome Measure(s)</title><p>IVF outcomes, including egg quality, the percentage of mature oocytes, fertilization rate, blastocyst formation rate, advanced embryo rate, and cumulative live birth rate were investigated. Auto-immune parameters, peripheral blood immunophenotypes, thyroid hormone, homocysteine, and 25-OH-vitamin D<sub>3</sub> (25-OH-VD<sub>3</sub>) levels were analyzed.</p></sec><sec><title>Results</title><p>The percentage of mature oocytes and blastocyst formation rate were significantly lower in the IR group as compared with those of the non-IR group (p&lt;0.05, respectively). The proportion of peripheral blood CD19<sup>+</sup> B cells was significantly higher in the IR group than those of the non-IR group (p&lt;0.05). Homocysteine, 25-OH-VD<sub>3,</sub> and auto-immune parameters were the same between the two groups.</p></sec><sec><title>Conclusion</title><p>In lean infertile women without PCOS, IR is associated with the decreased percentage of mature eggs and poor embryo quality in which B cell immunity may play a role.</p></sec>