AUTHOR=Chen Hao-Jie , Ngowi Ebenezeri Erasto , Qian Lei , Li Tao , Qin Yang-Zhe , Zhou Jing-Jing , Li Ke , Ji Xin-Ying , Wu Dong-Dong 

TITLE=Role of Hydrogen Sulfide in the Endocrine System

JOURNAL=Frontiers in Endocrinology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.704620

DOI=10.3389/fendo.2021.704620

ISSN=1664-2392

ABSTRACT=<p>Hydrogen sulfide (H<sub>2</sub>S), as one of the three known gaseous signal transduction molecules in organisms, has attracted a surging amount of attention. H<sub>2</sub>S is involved in a variety of physiological and pathological processes in the body, such as dilating blood vessels (regulating blood pressure), protecting tissue from ischemia-reperfusion injury, anti-inflammation, carcinogenesis, or inhibition of cancer, as well as acting on the hypothalamus and pancreas to regulate hormonal metabolism. The change of H<sub>2</sub>S concentration is related to a variety of endocrine disorders, and the change of hormone concentration also affects the synthesis of H<sub>2</sub>S. Understanding the effect of biosynthesis and the concentration of H<sub>2</sub>S on the endocrine system is useful to develop drugs for the treatment of hypertension, diabetes, and other diseases.</p>