AUTHOR=Albertelli Manuela , Grillo Federica , Lo Calzo Fabio , Puliani Giulia , Rainone Carmen , Colao Annamaria Anita Livia , Faggiano Antongiulio , NIKE group , Altieri Barbara , Barrea Luigi , Bottiglieri Filomena , Campione Severo , De Cicco Federica , Di Molfetta Sergio , Dicitore Alessandra , Dolci Carlotta , Feola Tiziana , Fanciulli Giuseppe , Ferone Diego , Ferraù Francesco , Gallo Marco , Giannetta Elisa , Grossrubatscher Erika , Guadagno Elia , Guarnotta Valentina , Isidori Andrea M. , Lania Andrea , Lenzi Andrea , Malandrino Pasquale , Messina Erika , Modica Roberta , Muscogiuri Giovanna , Pes Luca , Pizza Genoveffa , Pofi Riccardo , Razzore Paola , Rizza Laura , Rubino Manila , Ruggieri Rosa Maria , Sbardella Emilia , Sesti Franz , Venneri Mary Anna , Vitale Giovanni , Zatelli Maria Chiara TITLE=Pathology Reporting in Neuroendocrine Neoplasms of the Digestive System: Everything You Always Wanted to Know but Were Too Afraid to Ask JOURNAL=Frontiers in Endocrinology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.680305 DOI=10.3389/fendo.2021.680305 ISSN=1664-2392 ABSTRACT=

During the 5th NIKE (Neuroendocrine tumors Innovation in Knowledge and Education) meeting, held in Naples, Italy, in May 2019, discussions centered on the understanding of pathology reports of gastroenetropancreactic neuroendocrine neoplasms. In particular, the main problem concerned the difficulty that clinicians experience in extrapolating relevant information from neuroendocrine tumor pathology reports. During the meeting, participants were asked to identify and rate issues which they have encountered, for which the input of an expert pathologist would have been appreciated. This article is a collection of the most rated questions and relative answers, focusing on three main topics: 1) morphology and classification; 2) Ki67 and grading; 3) immunohistochemistry. Patient management should be based on multidisciplinary decisions, taking into account clinical and pathology-related features with clear comprehension between all health care professionals. Indeed, pathologists require clinical details and laboratory findings when relevant, while clinicians require concise and standardized reports. In keeping with this last statement, the minimum requirements in pathology datasets are provided in this paper and should be a baseline for all neuroendocrine tumor professionals.