AUTHOR=Moser Othmar , Eckstein Max L. , Mueller Alexander , Tripolt Norbert J. , Yildirim Hakan , Abbas Farah , Pferschy Peter N. , Goswami Nandu , Aberer Felix , Obermayer Anna , Pieber Thomas R. , Kojzar Harald , Sourij Caren , Brunner Martina , Niedrist Tobias , Herrmann Markus , Sourij Harald
TITLE=Impact of a Single 36 Hours Prolonged Fasting Period in Adults With Type 1 Diabetes – A Cross-Over Controlled Trial
JOURNAL=Frontiers in Endocrinology
VOLUME=12
YEAR=2021
URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.656346
DOI=10.3389/fendo.2021.656346
ISSN=1664-2392
ABSTRACT=Prolonged fasting has shown beneficial effects in healthy individuals and in people with chronic diseases. In type 1 diabetes, the effect or even the feasibility of fasting is unclear. We aimed to assess the impact and safety of prolonged fasting in adults with type 1 diabetes. Glycemia was assessed during overnight fasting (12 hours) vs. prolonged fasting (36 hours) via an intermittently-scanned continuous glucose monitoring system. Anthropometric data, metabolic and hormonal markers were compared between both trial arms. After each fasting period, a 75 g oral glucose tolerance test was performed and plasma glucose levels and hormones were assessed. Data were compared via paired t-tests and mixed-model regressions (p ≤ 0.05). Twenty individuals with type 1 diabetes (7 females) with a mean ± SD age of 35 ± 11 years, body mass index (BMI) 24.8 ± 2.8 kg/m2 and HbA1c 54 ± 7 mmol/mol were included. Hypoglycemia/hour (70 mg/dL; <3.9 mmol/L) was similar in both trial arms (12 hrs: 0.07 ± 0.06 vs. 36 hrs: 0.05 ± 0.03, p=0.21). Glycemic excursions during the oral glucose tolerance test were not different after the two fasting periods. Beta-hydroxybutyrate levels were higher after prolonged fasting (p=0.0006). Our study showed that people with type 1 diabetes can safely perform a 36 hours fasting period with a low risk of hypoglycemia and ketoacidosis.
Clinical Trial RegistrationDRKS.de, identifier DRKS00016148.