AUTHOR=Zhang Jiaxin , Hu Linli , Bu Zhiqin , Sun Yingpu 

TITLE=Impact of Uterine Adenomyosis on Pregnancy Outcomes in Women Undergoing In Vitro Fertilization Treated With a Long-Term Pituitary Downregulation Protocol

JOURNAL=Frontiers in Endocrinology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.655803

DOI=10.3389/fendo.2021.655803

ISSN=1664-2392

ABSTRACT=<sec><title>Background</title><p>Some studies have demonstrated that adenomyosis patients can achieve a comparable pregnancy outcome with women with normal uteruses, while there is no unanimous conclusion at present.</p></sec><sec><title>Method</title><p>We recruited 65 adenomyosis patients and 260 frequency-matched control women with endometriosis at a ratio of 1:4 according to age. Clinical pregnancy rate, spontaneous abortion rate, and live birth rate were compared between these two groups after controlling other factors.</p></sec><sec><title>Results</title><p>Compared with endometriosis patients, adenomyosis patients had a higher antral follicle count (AFC) (12.71 <italic>vs</italic> 11.65, <italic>P</italic>=0.027). Though the two groups had the same number of embryos transferred, adenomyosis patients had an obviously declined implantation rate (31.91% <italic>vs</italic> 46.74%, <italic>P</italic>=0.005), clinical pregnancy rate (47.06% <italic>vs</italic> 64.42%, P=0.028), live birth rate (31.37% <italic>vs</italic> 54.81%, P=0.004), and significantly increased spontaneous abortion rate (33.33% <italic>vs</italic> 13.43%, P=0.034). Multivariate logistic regression analysis showed that adenomyosis had adverse influences on pregnancy outcome when age and the number of embryo transfers were controlled (adjusted OR=0.361, P=0.003).</p></sec><sec><title>Conclusion</title><p>Even after being matched with age, adenomyosis still had adverse influences on the pregnancy outcome of IVF in patients undergoing the long protocol.</p></sec>