AUTHOR=Gui Weiwei , Liang Julong , Lin Xihua , Shi Nanjing , Zhu Yiyi , Tan Bowen , Li Hong 

TITLE=Association of Genetic Variants in IGF2-Related Genes With Risk of Metabolic Syndrome in the Chinese Han Population

JOURNAL=Frontiers in Endocrinology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.654747

DOI=10.3389/fendo.2021.654747

ISSN=1664-2392

ABSTRACT=<sec><title>Aims</title><p>To explore associations between polymorphisms of <italic>IGF2</italic>-related genes including <italic>H19</italic>, <italic>IGF2</italic>, <italic>IGF2BP2</italic> and <italic>IGF2R</italic> and Metabolic syndrome (MetS) susceptibility in the Chinese Han population.</p></sec><sec><title>Methods</title><p>66 subjects with MetS and 257 control subjects were collected for inclusion in a case-control study. PCR-RFLP was used to investigate polymorphisms in the <italic>H19</italic>, <italic>IGF2</italic>, <italic>IGF2BP2</italic> and <italic>IGF2R</italic> genes. Elisa was used to detect the serum <italic>IGF2</italic> concentrations.</p></sec><sec><title>Results</title><p>Females carrying the GG and AG genotypes of rs680 (<italic>IGF2)</italic> exhibited a lower risk of MetS, compared with those harboring AA (adjusted OR = 0.388, <italic>p</italic> = 0.027), while GG and AG genotypes were associated with lower fasting glucose and HbA1c. In males, the Waist-to-Hip Ratio (WHR) and the level of TG were significantly higher in GG and AG genotypes than in the AA genotype of rs680 in <italic>IGF2</italic>. Levels of HDL-c were lower in men with GG and AG genotypes compared with those carrying the AA genotype. Serum <italic>IGF2</italic> concentrations did not change among different genotypes. Finally, multifactor dimensionality reduction (MDR) analysis identified interactions between four polymorphisms: rs3741279 (<italic>H19</italic>), rs680 (<italic>IGF2</italic>), rs1470579 (<italic>IGF2BP2</italic>) and rs629849 (<italic>IGF2R</italic>).</p></sec><sec><title>Conclusions</title><p>Our study suggests that <italic>IGF2</italic>-related genes including <italic>H19</italic>, <italic>IGF2</italic>, <italic>IGF2BP2</italic> and <italic>IGF2R</italic> genes may play pivotal roles in the development of MetS.</p></sec>