AUTHOR=Lania Andrea , Ferraù Francesco , Rubino Manila , Modica Roberta , Colao Annamaria , Faggiano Antongiulio TITLE=Neoadjuvant Therapy for Neuroendocrine Neoplasms: Recent Progresses and Future Approaches JOURNAL=Frontiers in Endocrinology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.651438 DOI=10.3389/fendo.2021.651438 ISSN=1664-2392 ABSTRACT=

Neuroendocrine neoplasms (NENs) are a heterogeneous group of tumors, their treatment being challenging and requiring a multidisciplinary approach. Though the only curative treatment is surgery, up to 50% of patients are diagnosed with metastatic disease. In the last years, neoadjuvant chemo(radio)therapy has become part of the standard of care in the treatment of different cancer types. However, evidence of its efficacy and safety in NEN patients has not yet been confirmed in the literature. The aim of the present review is to perform an extensive review of the scientific evidence for neoadjuvant therapy in patients with gastroenteropancreatic and thoracic NENs.