AUTHOR=Luo Chun , Hu Chongyu , Li Bingyang , Liu Junyu , Hu Liming , Dong Rui , Liao Xin , Zhou Jilin , Xu Lu , Liu Songlin , Li Yifeng , Yuan Dun , Jiang Weixi , Yan Junxia 

TITLE=Polymorphisms in Lysyl Oxidase Family Genes Are Associated With Intracranial Aneurysm Susceptibility in a Chinese Population

JOURNAL=Frontiers in Endocrinology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.642698

DOI=10.3389/fendo.2021.642698

ISSN=1664-2392

ABSTRACT=<sec><title>Purpose</title><p>Intracranial aneurysms (IA) comprise a multifactorial disease with unclear physiological mechanisms. The lysyl oxidase (<italic>LOX</italic>) family genes (<italic>LOX</italic>, <italic>LOX–like 1–4</italic>) plays important roles in extracellular matrix (ECM) reconstruction and has been investigated in terms of susceptibility to IA in a few populations. We aimed to determine whether polymorphisms in <italic>LOX</italic> family genes are associated with susceptibility to IA in a Chinese population.</p></sec><sec><title>Methods</title><p>This case-control study included 384 patients with IA and 384 healthy individuals without IA (controls). We genotyped 27 single nucleotide polymorphisms (SNPs) of <italic>LOX</italic> family genes using the Sequenom MassARRAY<sup>®</sup> platform. These SNPs were adjusted for known risk factors and then, odds ratios (OR) and 95% confidence intervals (CI) were evaluated using binary logistic regression analysis.</p></sec><sec><title>Results</title><p>The result showed that <italic>LOX</italic> rs10519694 was associated with the risk of IA in recessive (OR, 3.88; 95% CI, 1.12–13.47) and additive (OR, 1.56; 95%CI, 1.05–2.34) models. Stratified analyses illustrated that <italic>LOX</italic> rs10519694 was associated with the risk of single IA in the recessive (OR, 3.95; 95%CI, 1.04–15.11) and additive (OR, 1.64; 95%CI, 1.04–2.56) models. The <italic>LOXL2</italic> rs1010156 polymorphism was associated with multiple IA in the dominant model (OR, 1.92; 95%CI, 1.02–3.62). No associations were observed between SNPs of <italic>LOXL1</italic>, <italic>LOXL3</italic>, and <italic>LOXL4</italic> and risk of IA.</p></sec><sec><title>Conclusion</title><p><italic>LOX</italic> and <italic>LOXL2</italic> polymorphisms were associated with risk of single IA and multiple IA in a Chinese population, suggesting potential roles of these genes in IA. The effects of these genes on IA require further investigation.</p></sec>