AUTHOR=Yoon Ha Young , Lee Min Hye , Song Yubin , Yee Jeong , Song Gonjin , Gwak Hye Sun 

TITLE=ABCA1 69C>T Polymorphism and the Risk of Type 2 Diabetes Mellitus: A Systematic Review and Updated Meta-Analysis

JOURNAL=Frontiers in Endocrinology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.639524

DOI=10.3389/fendo.2021.639524

ISSN=1664-2392

ABSTRACT=<sec><title>Background</title><p>The ATP-binding cassette transporter A1 <italic>(ABCA1)</italic> is likely associated with the risk of type 2 diabetes mellitus (T2DM) <italic>via</italic> β cell function modification, but the evidence on the association remains unclear. This study aimed to investigate the relationship between the <italic>ABCA1</italic> 69C&gt;T polymorphism and the risk of T2DM through a systematic review and meta-analysis.</p></sec><sec><title>Materials and Methods</title><p>The PubMed, Web of Science, and Embase databases were searched for qualified studies published until August 2020. Studies that included the association between the <italic>ABCA1</italic> 69C&gt;T polymorphism and the risk of T2DM were reviewed. The odds ratios (ORs) and 95% confidence intervals (CIs) were evaluated.</p></sec><sec><title>Results</title><p>We analyzed data from a total of 10 studies involving 17,742 patients. We found that the CC or CT genotype was associated with increased risk of T2DM than the TT genotype (OR, 1.41; 95% CI, 1.02-1.93). In the Asian population, the C allele carriers had a higher risk of T2DM than those with the TT genotype; the ORs of the CC and CT genotypes were 1.80 (95% CI, 1.21-2.68) and 1.61 (95% CI, and 1.29-2.01), respectively.</p></sec><sec><title>Conclusions</title><p>This meta-analysis confirmed that the <italic>ABCA1</italic> 69C&gt;T genotype showed a decrease risk of T2DM compared to the CC or CT genotypes.</p></sec>