AUTHOR=Li Baofeng , Wang Renkai , Huang Xianyin , Ou Yongliang , Jia Zhenyu , Lin Shanghui , Zhang Ying , Xia Hong , Chen Bei 

TITLE=Extracorporeal Shock Wave Therapy Promotes Osteogenic Differentiation in a Rabbit Osteoporosis Model

JOURNAL=Frontiers in Endocrinology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.627718

DOI=10.3389/fendo.2021.627718

ISSN=1664-2392

ABSTRACT=<p>Extracorporeal shock wave therapy (ESWT) has been identified to accelerate bone formation. However, detailed mechanism has not been fully explained. In this study, we found that ESWT promoted osteoblast formation <italic>in vitro</italic>. Local ESW treatment of femur increased bone formation <italic>in vivo</italic>. Furthermore, changing the density or frequency of energy, there was no statistical difference in osteogenic differentiation. Therapeutically, local ESW therapy relieved bone loss and increased the number of bone trabecular in a rabbit osteoporosis model and promoted endogenous levels of SMAD2 protein expression. Thus, ESWT may be a potential therapy by promoting osteoblast maturation through TGF-β/SMAD2 pathway.</p>