AUTHOR=Wang Guiming , Yang Yudong , Ma Honggang , Shi Liuming , Jia Wenbin , Hao Xing , Liu Weizong 

TITLE=LncRNA FENDRR Inhibits ox-LDL Induced Mitochondrial Energy Metabolism Disorder in Aortic Endothelial Cells via miR-18a-5p/PGC-1α Signaling Pathway

JOURNAL=Frontiers in Endocrinology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.622665

DOI=10.3389/fendo.2021.622665

ISSN=1664-2392

ABSTRACT=<p>Atherosclerosis (AS) is the main cause of morbidity and mortality in the world. Mitochondrial dysfunction is closely related to AS. At present, several signaling pathways related to mitochondrial dysfunction have been found, one of which is around PGC-1<italic>α</italic>. PGC-1<italic>α</italic> is a transcription activator, which is related to mitochondrial biogenesis and antioxidant defense. In this study, we explored the effect of miR-18a-5p/PGC-1<italic>α</italic> signaling pathway on mitochondrial energy metabolism in HAECs with ox-LDL treatment. The results showed that the mitochondrial energy metabolism disorder in HAECs treated by ox-LDL was related to the downregulation of LncRNA FENDRR and PGC-1<italic>α</italic>. FENDRR could reverse ox-LDL induced mitochondrial energy metabolism disorder and upregulate the PGC-1<italic>α</italic> expression. FENDRR could be used as ceRNA to inhibit the miR-18a-5p expression and reduce the negative regulation of miR-18a-5p on PGC-1<italic>α</italic>. Downregulation of miR-18a-5p expression or upregulation of PGC-1<italic>α</italic> in ox-LDL treated HAECs could reverse mitochondrial energy metabolism disorder. In conclusion, these findings suggested that FENDRR/miR-18a-5p/PGC-1<italic>α</italic> signaling pathway regulated mitochondrial energy metabolism in HAECs; ox-LDL downregulated the expression of PGC-1<italic>α</italic> and cause mitochondrial energy metabolism disorder by inhibiting this signal pathway.</p>