AUTHOR=Odagiu Livia , May Julia , Boulet Salix , Baldwin Troy A. , Labrecque Nathalie 

TITLE=Role of the Orphan Nuclear Receptor NR4A Family in T-Cell Biology

JOURNAL=Frontiers in Endocrinology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2020.624122

DOI=10.3389/fendo.2020.624122

ISSN=1664-2392

ABSTRACT=<p>The nuclear orphan receptors NR4A1, NR4A2, and NR4A3 are immediate early genes that are induced by various signals. They act as transcription factors and their activity is not regulated by ligand binding and are thus regulated <italic>via</italic> their expression levels. Their expression is transiently induced in T cells by triggering of the T cell receptor following antigen recognition during both thymic differentiation and peripheral T cell responses. In this review, we will discuss how NR4A family members impact different aspects of the life of a T cell from thymic differentiation to peripheral response against infections and cancer.</p>