AUTHOR=Zhao Yiming , Liang Weiwei , Cai Feng , Wu Qun , Wang Yongjian 

TITLE=Fluconazole for Hypercortisolism in Cushing’s Disease: A Case Report and Literature Review

JOURNAL=Frontiers in Endocrinology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2020.608886

DOI=10.3389/fendo.2020.608886

ISSN=1664-2392

ABSTRACT=<sec><title>Background</title><p>Cushing’s disease is associated with an increased risk of pulmonary fungal infection, which could be a relative contraindication for pituitary adenoma excision surgery.</p></sec><sec><title>Case</title><p>We report a case of a patient with Cushing’s disease and pulmonary <italic>Cryptococcus neoformans</italic>. A 48-year-old woman was admitted to our hospital because of moon face and edema. Laboratory and radiological findings suggested a diagnosis of Cushing’s disease and pulmonary cryptococcus infection. Fluconazole 400 mg per day was administered intravenously and continued orally for 3 months. Both cryptococcus infection and hypercortisolism relieved and transsphenoidal resection was performed.</p></sec><sec><title>Conclusion</title><p>Cushing’s disease can be effectively treated with fluconazole to normalize cortisol concentration prior to pituitary surgery. Fluconazole is an alternative treatment especially in Cushing’s disease patients with cryptococcal pneumonia.</p></sec>