AUTHOR=Dewailly Didier , Barbotin Anne-Laure , Dumont Agathe , Catteau-Jonard Sophie , Robin Geoffroy 

TITLE=Role of Anti-Müllerian Hormone in the Pathogenesis of Polycystic Ovary Syndrome

JOURNAL=Frontiers in Endocrinology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2020.00641

DOI=10.3389/fendo.2020.00641

ISSN=1664-2392

ABSTRACT=<p>Besides its interest for diagnosis, the finding of an elevated serum AMH level in PCOS has open major pathophysiological issues. This review addresses the three most important issues: 1- the role of AMH in the disturbed folliculogenesis of PCOS; 2- the role of AMH in the gonadotropin dysregulation of PCOS and 3- the role of AMH in the trans-generational transmission of PCOS. For each of those issues, the clinical and experimental evidences currently available are discussed and pathophysiological hypothesis are proposed.</p>