AUTHOR=García-Costela María , Escudero-Feliú Julia , Puentes-Pardo Jose D. , San Juán Sara Moreno , Morales-Santana Sonia , Ríos-Arrabal Sandra , Carazo Ángel , León Josefa 

TITLE=Circadian Genes as Therapeutic Targets in Pancreatic Cancer

JOURNAL=Frontiers in Endocrinology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2020.00638

DOI=10.3389/fendo.2020.00638

ISSN=1664-2392

ABSTRACT=<p>Pancreatic cancer is one of the most lethal cancers worldwide due to its symptoms, early metastasis, and chemoresistance. Thus, the mechanisms contributing to pancreatic cancer progression require further exploration. Circadian rhythms are the daily oscillations of multiple biological processes regulated by an endogenous clock. Several evidences suggest that the circadian clock may play an important role in the cell cycle, cell proliferation and apoptosis. In addition, timing of chemotherapy or radiation treatment can influence the efficacy and toxicity treatment. Here, we revisit the studies on circadian clock as an emerging target for therapy in pancreatic cancer. We highlight those potential circadian genes regulators that are commonly affected in pancreatic cancer according to most recent reports.</p>