AUTHOR=Liu Zeming , Li Jinpeng , Huang Jianglong , Guo Liang , Gao Rongfen , Luo Kuan , Zeng Guang , Zhang Tingbao , Yi Meilin , Huang Yihui , Chen Jincao , Yang Yibin , Wu Xiaohui 

TITLE=Association Between Diabetes and COVID-19: A Retrospective Observational Study With a Large Sample of 1,880 Cases in Leishenshan Hospital, Wuhan

JOURNAL=Frontiers in Endocrinology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2020.00478

DOI=10.3389/fendo.2020.00478

ISSN=1664-2392

ABSTRACT=<p><bold>Aims:</bold> This study aimed to investigate the clinical courses and outcomes of diabetes mellitus patients with coronavirus disease 2019 (COVID-19) in Wuhan.</p><p><bold>Methods:</bold> This study enrolled 1,880 consecutive patients with confirmed COVID-19 in Leishenshan Hospital. We collected and analyzed their data, including demographic data, history of comorbidity, clinical symptoms, laboratory tests, chest computed tomography (CT) images, treatment options, and survival.</p><p><bold>Results:</bold> The percentages of patients with diabetes among the severe and critical COVID-19 cases were higher than those among the mild or general cases (89.2%, 10.8 vs. 0%, <italic>p</italic> = 0.001). However, patients with and without diabetes showed no difference in the follow-up period (<italic>p</italic> = 0.993). The mortality rate in patients with or without diabetes was 2.9% (<italic>n</italic> = 4) and 1.1% (<italic>n</italic> = 9), respectively (<italic>p</italic> = 0.114). Univariate and multivariate Cox regression analyses and the Kaplan-Meier curves did not show any statistically significant differences between patients with and without diabetes (all <italic>p</italic> &gt; 0.05).</p><p><bold>Conclusions:</bold> Our study results suggested that diabetes had no effect on the prognosis of COVID-19 patients but had a negative association with their clinical courses. These results may be useful for clinicians in the management of diabetic patients with COVID-19.</p>