AUTHOR=Wan Ji-Peng , Wang Zhen-Jing , Sheng Yan , Chen Wei , Guo Qing-Qing , Xu Jin , Fan Hua-Rui , Sun Mei 

TITLE=Effect of HCG-Triggered Ovulation on Pregnancy Outcomes in Intrauterine Insemination: An Analysis of 5,610 First IUI Natural Cycles With Donor Sperm in China

JOURNAL=Frontiers in Endocrinology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2020.00423

DOI=10.3389/fendo.2020.00423

ISSN=1664-2392

ABSTRACT=<p><bold>Objective:</bold> To evaluate the effect of human chorionic gonadotropin (hCG) trigger ovulation on pregnancy outcomes in natural IUI cycles with donor sperm.</p><p><bold>Methods:</bold> This retrospective cohort study included 5,610 first-natural IUI cycles with donor sperm in infertile couples during the period from January 2012 to December 2017. To control for other confounding factors, our analysis was restricted to normo-ovulatory women without tubal infertility. The main outcome measure was live birth rate; the secondary outcomes included rates of clinical pregnancy and miscarriage.</p><p><bold>Results:</bold> In the crude analysis, both the clinical pregnancy (27.40 vs. 22.73%; <italic>P</italic> = 0.001) and live birth rates (24.52 vs. 20.13%; <italic>P</italic> = 0.007) were significantly higher for the hCG group than for the spontaneous LH group. After adjustment for a number of confounding factors, the reproductive outcomes were still significantly worse for the spontaneous ovulatory group.</p><p><bold>Conclusions:</bold> Among women undergoing natural cycle IUI with donor sperm, hCG triggered ovulation for timing insemination offers beneficial impacts on both clinical pregnancy rates and live birth rates.</p>