AUTHOR=Niu Yiqi , Ding Zheng , Deng Xianzhao , Guo Bomin , Kang Jie , Wu Bo , Fan Youben 

TITLE=A Novel Multimodal Therapy for Anaplastic Thyroid Carcinoma: 125I Seed Implantation Plus Apatinib After Surgery

JOURNAL=Frontiers in Endocrinology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2020.00207

DOI=10.3389/fendo.2020.00207

ISSN=1664-2392

ABSTRACT=<p>Anaplastic thyroid cancer is known to be the most lethal malignancy among endocrine tumors for its extremely limited survival rate after diagnosis. As a result of this poor survival prognosis, multimodal therapy is currently under investigation to address this global concern. In this reported case, the <sup>125</sup>I seed implantation and vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor apatinib were co-applied to treat a 49-year-old woman with anaplastic thyroid cancer. After the patient began apatinib administration and underwent <sup>125</sup>I seed implantation twice, the tumor size shrank successfully. After a follow-up of 13 months since the initial diagnosis of anaplastic thyroid cancer, the patient survived with a stable disease pathology. In conclusion, this study supports <sup>125</sup>I seed implantation and apatinib as effective therapeutic alternatives for inoperable anaplastic thyroid cancer patients.</p>