AUTHOR=Liu Jia , Fan Wenliang , Jia Yuxi , Su Xiaoyun , Wu Wenjun , Long Xi , Sun Xin , Liu Jie , Sun Wengang , Zhang Tianjing , Gong Qiyong , Shi Haojun , Zhu Qing , Wang Jing 

TITLE=Altered Gray Matter Volume in Patients With Type 1 Diabetes Mellitus

JOURNAL=Frontiers in Endocrinology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2020.00045

DOI=10.3389/fendo.2020.00045

ISSN=1664-2392

ABSTRACT=<p><bold>Background and Purpose:</bold> Many imaging studies have reported structure alterations in patients with type 1 diabetes mellitus (T1DM) by using voxel-based morphometry (VBM). Nevertheless, the results reported were inconsistent and had not been reviewed quantitatively. Accordingly, the quantitative meta-analysis which including VBM studies of patients with T1DM was conducted.</p><p><bold>Materials and Methods:</bold> The gray matter volume alterations in patients with T1DM was estimated by using the software seed-based d mapping. Meantime, the meta-regression was applied to detect the effects of some demographics and clinical characteristics.</p><p><bold>Results:</bold> Six studies were finally included, which with 6 datasets comprising 414 T1DM patients and 216 healthy controls. The pooled meta-analyses detected that patients with T1DM showed robustly increased gray matter volume in the left dorsolateral superior frontal gyrus and middle frontal gyrus and a decreased gray matter volume in the right lingual gyrus, cerebellum, precuneus, the left inferior temporal gyrus, and middle temporal gyrus. The meta-regression showed that the mean age, the female patient's ratio, duration of illness and HbAlc% for T1DM patients were not linearly related with gray matter alterations.</p><p><bold>Conclusion:</bold> This meta-analysis demonstrates that gray matter volume decreases in T1DM patients were mainly locates in the cortical regions and cerebellum.</p>