AUTHOR=Li Wei , Li Yong , Qiu Qi , Sun Lin , Yue Ling , Li Xia , Xiao Shifu 

TITLE=Associations Between the Apolipoprotein E ε4 Allele and Reduced Serum Levels of High Density Lipoprotein a Cognitively Normal Aging Han Chinese Population

JOURNAL=Frontiers in Endocrinology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2019.00827

DOI=10.3389/fendo.2019.00827

ISSN=1664-2392

ABSTRACT=<p><bold>Background:</bold> Previous studies have confirmed that <italic>APOE</italic> genotype is associated with lipid metabolism, but related studies are inconsistent. Therefore, we conducted this cross-sectional study to explore the associations between apolipoprotein E (<italic>APOE</italic>) genotypes and serum levels of fasting blood sugar, triglycerides, total cholesterol, high density lipoprotein, and low density lipoprotein in a cognitively normal aging Han Chinese population.</p><p><bold>Methods:</bold> One hundred sixty-nine community elders with normal cognitive function were included in the study. Based on multiplex amplification refractory mutation system polymerase chain reaction (PCR), these subjects were divided into three groups: (1) E2/2 or E2/3 (<italic>APOE</italic> E2); (2) E3/3 (<italic>APOE</italic> E3); and (3) E2/4, E3/4, or E4/4 (<italic>APOE</italic> E4). Correlations of serum levels of fasting blood sugar, triglycerides, total cholesterol, high density lipoprotein, and low density lipoprotein with <italic>APOE</italic> genotypes were assessed.</p><p><bold>Results:</bold> The results of Mann-Whitney analysis showed that the concentration of high density lipoprotein (HDL) in <italic>APOE</italic> E2 and E3 groups was higher than that in E4 groups (<italic>p</italic> &lt; 0.05). Logistic regression analysis also suggested that a lower level of high density lipoprotein was associated with the E4 allele (adjusted odds ratio 0.164, 95% confidence interval 0.031~ 0.876, <italic>P</italic> = 0.034).</p><p><bold>Conclusion:</bold><italic>APOE</italic> E4 is associated with decreased serum high density lipoprotein concentration in healthy elderly. However, the above conclusions need to be further verified.</p>