AUTHOR=Zou Huajie , Yin Ping , Liu Liegang , Liu Wenhua , Zhang Zeqing , Yang Yan , Li Wenjun , Zong Qunchuan , Yu Xuefeng 

TITLE=Body-Weight Fluctuation Was Associated With Increased Risk for Cardiovascular Disease, All-Cause and Cardiovascular Mortality: A Systematic Review and Meta-Analysis

JOURNAL=Frontiers in Endocrinology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2019.00728

DOI=10.3389/fendo.2019.00728

ISSN=1664-2392

ABSTRACT=<p><bold>Background:</bold> The aim of this study was to evaluate associations between body-weight fluctuation and risk of mortality and cardiovascular diseases (CVD).</p><p><bold>Methods:</bold> PubMed, EMBASE databases and Cochrane Library were searched for cohort studies published up to May 20, 2019, reporting on associations of body-weight fluctuation and mortality from all causes, CVD and cancer, as well as morbidity of CVD and hypertension. Summary relative risks (RRs) were estimated using a random-effects model.</p><p><bold>Results:</bold> Twenty-five eligible publications from 23 studies with 441,199 participants were included. Body-weight fluctuation was associated with increased risk for all-cause mortality (RR, 1.41; 95% confidence interval (CI): 1.27–1.57), CVD mortality (RR, 1.36; 95% CI 1.22–1.52), and morbidity of CVD (RR, 1.49, 95% CI 1.26–1.76) and hypertension (RR, 1.35, 95% CI 1.14–1.61). However, there was no significant association between weight fluctuation and cancer mortality (RR, 1.01; 95% CI 0.90–1.13). No evidence of publication bias was observed (all <italic>P</italic> &gt; 0.05) except for studies on all-cause mortality (Egger's test, <italic>P</italic> = 0.001; Begg's test, <italic>P</italic> = 0.014).</p><p><bold>Conclusions:</bold> Body-weight fluctuation was associated with higher mortality due to all causes and CVD and a higher morbidity of CVD and hypertension.</p>