AUTHOR=Männistö Jonna M. E. , Jääskeläinen Jarmo , Huopio Hanna 

TITLE=Health-Related Quality of Life in Children With Congenital Hyperinsulinism

JOURNAL=Frontiers in Endocrinology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2019.00670

DOI=10.3389/fendo.2019.00670

ISSN=1664-2392

ABSTRACT=<p><bold>Background:</bold> Quality of life (QoL) has not been studied in patients with congenital hyperinsulinism (CHI).</p><p><bold>Objectives:</bold> To examine whether the health-related quality of life (HRQoL) is worsened in patients with persistent or transient CHI.</p><p><bold>Methods:</bold> We studied HRQoL of 65 children with CHI aged 3–17 years (60% males) recruited from the nationwide CHI registry. The median ages were 9.6 (range 3.5–16.3) and 7.4 (3.1–17.9) years in persistent (P-CHI, <italic>n</italic> = 33) and transient (T-CHI, <italic>n</italic> = 32) CHI groups, respectively. HRQoL was examined by generic KINDL-R questionnaire and the scores were compared to the age- and gender-specific reference values.</p><p><bold>Results:</bold> In self-reports of subjects aged 11–17 years and in parent reports of children aged 3–17 years, P-CHI or T-CHI children did not have statistically lower scores in any of the six dimensions (physical well-being, emotional well-being, self-esteem, family, friends, and school) or in total scores compared to the reference values.</p><p><bold>Conclusions:</bold> CHI is not associated with low HRQoL in childhood or adolescence.</p>