AUTHOR=Martínez Muñoz Ilse Yessabel , Camarillo Romero Eneida del Socorro , Correa Padilla Trinidad , Santillán Benítez Jonnathan Guadalupe , Camarillo Romero María del Socorro , Montenegro Morales Laura Patricia , Bravo Gabriel Gerardo Huitrón , Garduño García José de Jesús 

TITLE=Association of Irisin Serum Concentration and Muscle Strength in Normal-Weight and Overweight Young Women

JOURNAL=Frontiers in Endocrinology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2019.00621

DOI=10.3389/fendo.2019.00621

ISSN=1664-2392

ABSTRACT=<p><bold>Background:</bold> Irisin is a muscle-contraction-induced myokine. In previous studies, it has been related to exercise type, fitness and physical activity; however, evidence is not consistent. Thus, the aim of this study was to research the association between health-related fitness and irisin in young women.</p><p><bold>Methods:</bold> The study was designed as a prospective cross-sectional one. Young, healthy, nonsmoking women were enlisted. The sample comprised 40 overweight (OW) and 40 normal-weight (NW) individuals. The average age was 18.63 ± 0.63 and 18.78 ± 0.73 years, respectively. Components of health-related fitness, metabolic parameters, serum irisin and body composition were analyzed.</p><p><bold>Results:</bold> Statistically significant differences were found in physical tests between NW and OW groups for one-leg standing, hand grip strength, vertical jump, modified push-up, fitness index and maximal oxygen uptake (VO<sub>2MAX</sub>). There were no differences in concentrations of serum irisin between the groups. We found a positive correlation between irisin and hand grip strength (<italic>r</italic> = 0.374, <italic>p</italic> = 0.023). In a multivariate analysis adjusted by body fat, a significant association between irisin and hand grip strength was observed in OW group (β = 0.380, <italic>p</italic> = 0.026); as well, a positive association between irisin and one-leg standing test in NW group (β = 0.311, <italic>p</italic> = 0.044) was found.</p><p><bold>Conclusions:</bold> According to our findings, hand grip strength could be linked to irisin concentration in overweight young women.</p>