AUTHOR=Li Yan-yan , Lu Xin-zheng , Yang Xin-xing , Wang Hui , Geng Hong-yu , Gong Ge , Zhan Yi-yang , Kim Hyun Jun , Yang Zhi-jian 

TITLE=GHRL Gene Leu72Met Polymorphism and Type 2 Diabetes Mellitus: A Meta-Analysis Involving 8,194 Participants

JOURNAL=Frontiers in Endocrinology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2019.00559

DOI=10.3389/fendo.2019.00559

ISSN=1664-2392

ABSTRACT=<p><bold>Background:</bold> Although many studies indicate a positive correlation between <italic>GHRL</italic> gene Leu72Met polymorphism and an increased susceptibility to type 2 diabetes mellitus (T2DM), inconsistencies between independent studies still remain.</p><p><bold>Objective:</bold> Considering the inconsistencies between them, we have performed the current meta-analysis study. The objective of this study is to better examine the correlation of the <italic>GHRL</italic> gene Leu72Met polymorphism and T2DM.</p><p><bold>Methods:</bold> The current meta-analysis, involving 8,194 participants from 11 independent studies, was performed. A fixed effect model was used to evaluate the pooled odds ratios (ORs) and the corresponding 95% confidence intervals (95% CIs).</p><p><bold>Results:</bold> A significant association was found between T2DM and <italic>GHRL</italic> gene Leu72Met polymorphism under recessive (OR: 1.33, 95% CI: 1.01–1.76, <italic>P</italic> = 0.04), and homozygous genetic models (OR: 1.34, 95% CI: 1.01–1.78, <italic>P</italic> = 0.04) in the whole population. The correlation was more distinct in our subgroup analysis of the Chinese population under recessive (OR: 1.52, 95% CI: 1.07–2.15, <italic>P</italic> = 0.02), dominant (OR: 1.70, 95% CI: 1.38–2.10, <italic>P</italic> &lt; 0.00001), additive (OR: 1.16, 95% CI: 1.02–1.33, <italic>P</italic> = 0.02), and homozygous genetic models (OR: 1.54, 95% CI: 1.07–2.20, <italic>P</italic> = 0.02).</p><p><bold>Conclusions:</bold> In short, <italic>GHRL</italic> gene Leu72Met polymorphism was significantly correlated with increased T2DM risk, particularly in the Chinese population. Individuals carrying the Met72 allele of <italic>GHRL</italic> Leu72Met gene polymorphism, particularly those of Chinese ancestry, may be more susceptible to developing T2DM disease.</p>