AUTHOR=Barbosa Margarida , Saavedra Ana , Oliveira Sofia , Reis Ligia , Rodrigues Filipa , Severo Milton , Sittl Reinhard , Maier Christoph , Carvalho Davide M. 

TITLE=Prevalence and Determinants of Painful and Painless Neuropathy in Type 1 Diabetes Mellitus

JOURNAL=Frontiers in Endocrinology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2019.00402

DOI=10.3389/fendo.2019.00402

ISSN=1664-2392

ABSTRACT=<p><bold>Aims:</bold> To evaluate (1) the prevalence of diabetic distal symmetrical sensory–motor polyneuropathy (DSPN) and painful DSPN among patients with type 1 diabetes mellitus (DM1) aged over 18 years and (2) the determinant factors of neuropathy and pain in those patients.</p><p><bold>Materials and Methods:</bold> An epidemiological, cross-sectional, observational study was performed; 330,386 people were included, and a total of 444 people were diagnosed with DM1. After exclusion of possible confounders, 360 patients were assessed for painless and painful DSPNs using neurological examination and questionnaires for neuropathy and pain. Odds ratio (OR) and confidence intervals (95% CI) were estimated using multinomial logistic regression models. The analysis was based on a framework with four conceptual levels that consider feasible pathways between several risk factors: (1) socio-demographic factors and diabetes duration, (2) patient habits, (3) co-morbidities, and (4) metabolic factors and disease complications.</p><p><bold>Results:</bold> The prevalence of DSPN and painful DSPN were 42.8 and 18.9%, respectively. Diabetes duration was positively associated with painful (OR = 1.107, 95% CI: 1.107–1.139) and painless DSPN (OR = 1.069, 95% CI: 1.043–1.096). Education level was negatively associated with painful DSPN (OR = 0.889, 95% CI: 0.826–0.957). Sex (female) was positively associated only with painless DSPN (OR = 1.769, 95% CI: 1.007–3.107). Being a current or former smoker was positively associated only with painless DSPN (OR = 1.940, 95% CI: 1.069–3.518). Hypertension was positively associated with painful DSPN (OR = 2.474, 95% CI: 1.110–5.512) and painless DSPN (OR = 2.565, 95% CI: 1.252–5.256). Glycated hemoglobin (HbA1c) was positively associated only with painless DSPN (OR = 1.193, 95% CI: 1.018–1.399).</p><p><bold>Conclusions:</bold> Diabetes duration and hypertension have a direct impact on the development of painful and painless DSPN. However, female sex and HbA1c have a direct effect only on the development of painless DSPN, and education level has an indirect effect on the development of painful DSPN. Therefore, it can be concluded that different etiological factors have different contributions to the development of neuropathy and pain.</p>