AUTHOR=Vethe Heidrun , Ghila Luiza , Berle Magnus , Hoareau Laurence , Haaland Øystein A. , Scholz Hanne , Paulo Joao A. , Chera Simona , Ræder Helge TITLE=The Effect of Wnt Pathway Modulators on Human iPSC-Derived Pancreatic Beta Cell Maturation JOURNAL=Frontiers in Endocrinology VOLUME=10 YEAR=2019 URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2019.00293 DOI=10.3389/fendo.2019.00293 ISSN=1664-2392 ABSTRACT=
Current published protocols for targeted differentiation of human stem cells toward pancreatic β-cells fail to deliver sufficiently mature cells with functional properties comparable to human islet β-cells. We aimed to assess whether Wnt-modulation could promote the final protocol stages of β-cell maturation, building our hypothesis on our previous findings of Wnt activation in immature hiPSC-derived stage 7 (S7) cells compared to adult human islets and with recent data reporting a link between Wnt/PCP and