AUTHOR=Poli Maurizio , Girardi Laura , Fabiani Marco , Moretto Martina , Romanelli Valeria , Patassini Cristina , Zuccarello Daniela , Capalbo Antonio 

TITLE=Past, Present, and Future Strategies for Enhanced Assessment of Embryo's Genome and Reproductive Competence in Women of Advanced Reproductive Age

JOURNAL=Frontiers in Endocrinology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2019.00154

DOI=10.3389/fendo.2019.00154

ISSN=1664-2392

ABSTRACT=<p>Recent advancements in genomic analysis allow testing of an increasing number of genetic features in human preimplantation embryos. Typical single gene mutation and whole chromosomes testing can now be integrated with assessment of mitochondrial DNA and polygenic conditions. Diagnostic expansion into epigenetic and transcriptomic assessment in the near future are potential technological targets which may improve the prognostic outlook of patients of advanced reproductive age and overall <italic>in vitro</italic> fertilization (IVF) treatment outcomes. In this review, we discuss the technological progress of recent years and their future applications in preimplantation genetic testing in IVF.</p>