AUTHOR=Kawabe Yuko , Waterson Hannah , Mizoguchi Akira 

TITLE=Bombyxin (Bombyx Insulin-Like Peptide) Increases the Respiration Rate Through Facilitation of Carbohydrate Catabolism in Bombyx mori

JOURNAL=Frontiers in Endocrinology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2019.00150

DOI=10.3389/fendo.2019.00150

ISSN=1664-2392

ABSTRACT=<p>Bombyxin-II, an insulin-like peptide of the silkmoth <italic>Bombyx mori</italic>, has been shown to reduce both the trehalose concentration in the hemolymph and the glycogen content in some tissues of <italic>B. mori</italic> larvae. However, little is known about how these storage carbohydrates are utilized. To address this question, the effects of bombyxin-II injection into <italic>Bombyx</italic> larvae on the tissue lipid level, respiration rate, and glycolytic activity of tissues were investigated. Bombyxin-II did not affect lipid accumulation in the hemolymph and fat body, while it increased the rate of oxygen consumption and increased the content of fructose 2, 6-bisphosphate, a potent activator of glycolysis, in the gonads, imaginal discs, and midgut. These results suggest that bombyxin facilitates cellular energy production thereby supporting the tissue growth of insects.</p>