AUTHOR=Decourcelle Amélie , Leprince Dominique , Dehennaut Vanessa 

TITLE=Regulation of Polycomb Repression by O-GlcNAcylation: Linking Nutrition to Epigenetic Reprogramming in Embryonic Development and Cancer

JOURNAL=Frontiers in Endocrinology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2019.00117

DOI=10.3389/fendo.2019.00117

ISSN=1664-2392

ABSTRACT=<p>Epigenetic modifications are major actors of early embryogenesis and carcinogenesis and are sensitive to nutritional environment. In recent years, the nutritional sensor <italic>O</italic>-GlcNAcylation has been recognized as a key regulator of chromatin remodeling. In this review, we summarize and discuss recent clues that OGT and <italic>O</italic>-GlcNAcylation intimately regulate the functions of the Polycomb group proteins at different levels especially during <italic>Drosophila melanogaster</italic> embryonic development and in human cancer cell lines. These observations define an additional connection between nutrition and epigenetic reprogramming associated to embryonic development and cancer.</p>