AUTHOR=Masclef Louis , Dehennaut Vanessa , Mortuaire Marlène , Schulz Céline , Leturcq Maïté , Lefebvre Tony , Vercoutter-Edouart Anne-Sophie TITLE=Cyclin D1 Stability Is Partly Controlled by O-GlcNAcylation JOURNAL=Frontiers in Endocrinology VOLUME=10 YEAR=2019 URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2019.00106 DOI=10.3389/fendo.2019.00106 ISSN=1664-2392 ABSTRACT=
Cyclin D1 is the regulatory partner of the cyclin-dependent kinases (CDKs) CDK4 or CDK6. Once associated and activated, the cyclin D1/CDK complexes drive the cell cycle entry and G1 phase progression in response to extracellular signals. To ensure their timely and accurate activation during cell cycle progression, cyclin D1 turnover is finely controlled by phosphorylation and ubiquitination. Here we show that the dynamic and reversible