AUTHOR=Gallo Mariagrazia , Licata Emanuele , Meneghini Caterina , Dal Lago Alessandro , Fabiani Cristina , Amodei Marcello , Antonaci Domenico , Miriello Donatella , Corno Roberta , Liberanome Carmelina , Bisogni Francescantonio , Paciotti Gemma , Meneghini Carlo , Rago Rocco 

TITLE=Impact of Paternal Age on Seminal Parameters and Reproductive Outcome of Intracytoplasmatic Sperm Injection in Infertile Italian Women

JOURNAL=Frontiers in Endocrinology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2019.00035

DOI=10.3389/fendo.2019.00035

ISSN=1664-2392

ABSTRACT=<p><bold>Background:</bold> We conducted a retrospective study on a cohort of couples attending the Department of Andrology and Reproductive Physiopathology at Sandro Pertini Hospital in Rome for Intracytoplasmatic Sperm Injection (ICSI)-assisted reproduction programs. Some of the couples included in the study underwent more than one ICSI cycle. Between January 2015 and April 2017.</p><p><bold>Objective:</bold> To evaluate whether the advancing of the paternal age may have effect on the seminal parameters, thus negatively affecting the embryo formation, development and quality, as well as the pregnancy rate.</p><p><bold>Materials and Methods:</bold> Five hundred and forty three ICSI cycles were performed on 439 couples undergoing Assisted Reproductive Technologies (ART). Patients were subdivided into three male and three female age groups having similar size:</p><p>Men: ≤38 years (M<sub>I</sub>), 39–43 years (M<sub>II</sub>), ≥44 years (M<sub>III</sub>).</p><p>Women: ≤35 years (F<sub>I</sub>), 36–40 years (F<sub>II</sub>),≥41 years (F<sub>III</sub>).</p><p><bold>Discussion and Conclusion:</bold> Male age groups did not reveal any statistical significant differences in any age-related semen parameters. We also confirmed a statistical significant increase in the pregnancy rate of couples with older partner age difference and younger female. We found that the advanced male age increases the probability of obtaining one or no type A embryo (N<sub>A</sub>≤1), which was almost doubled in the M<sub>III</sub> group in comparison with M<sub>I</sub>, suggesting a negative effect of male age on the efficacy of the reproductive outcome in terms of a reduced number of type A embryos. Such an effect does not seem related to semen parameters and may deserve further investigations.</p>